A recent clinical study evaluated the safety and efficacy of platelet-rich plasma (PRP) in 60 sexually-active men with mild and moderate erectile dysfunction (ED). The results showed that patients treated with PRP had a greater improvement in erectile function than those treated with saline.
Erectile dysfunction is a common problem that affects as many as 30 million men. It is a complex, multidimensional disorder that results from:
Most treatments for ED only focus on enhancing the blood flow to the penis without addressing the other contributing factors.
Interest in regenerative medicine has flourished in recent years, and PRP has emerged as a promising treatment for ED. Results from animal studies suggest that PRP injections may improve key elements of the processes that lead to ED through anti-inflammatory, reparative, neuroprotective, and neurotrophic effects.
However, widespread adoption of PRP for ED management has been slow due to the lack of high-quality human clinical trials.
The present study is the first double-blind, randomized, placebo-controlled clinical trial exploring the safety and efficacy of PRP injections in patients with non-severe ED.
To qualify for the trial, participants had to be sexually active 40- to 70-year-old males with mild and moderate ED. Other inclusion criteria were as follows:
After the 1-month initial screening and evaluation period, the subjects were randomized in a 1:1 ratio to either the PRP or the saline solution group. Both groups received their intracavernosal injections across two sessions, with the second injection one month after the first. All injections were concealed by tinfoil to ensure the study was double-blinded.
The investigators evaluated each patient 1, 3, and 6 months after completing the treatment protocol. At each follow-up visit, the patients were asked to return their completed SEP diaries for the last month and to fill out the IIEF-EF. The treatment was considered successful if the patient attained the minimally clinical important difference (MCID) on the IIEF-EF, defined as an improvement of:
At each follow-up visit, at least 69% of patients (20 of 29) in the PRP group attained an MCID, compared to 39% (10 of 26) or less in the placebo group. These results show a statistically significant advantage of PRP over saline in improving erectile function.
The patients in the PRP group also reported more satisfaction with their treatment and outcomes than the patients in the placebo group.
PRP is a promising addition to the management of erectile dysfunction. It is safe, cost-effective, and may actually regenerate damaged cells and blood vessels necessary for erectile function.
Call us today at 844-377-7787 (DR- PRP-US) to see how Dr. PRP can help your patients