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PRP + Fat Grafting

PRP + Fat Grafting

Fat grafting has been used as a reconstructive and cosmetic procedure for more than a century. Fat grafts have been used in procedures as varied as hernia repair, scar repair, rhinoplasty, breast reconstruction, breast augmentation, facial reconstruction, chin augmentation, and to correct the cosmetic signs of aging.

Fat tissue is probably the best filler available for a variety of reasons, including the fact that it is:

  • Readily available throughout the body
  • Easily obtainable
  • Inexpensive
  • Versatile
  • Biocompatible
  • Contains stem cells to aid in the regenerative process 1

However, the main problem with fat grafting is that only 30% of injected fat can be expected to survive for one year due to absorption. The reason for this is not entirely clear. However, two main theories have emerged. One theory - the host cell replacement theory - suggests that some transplanted fat completely dies due to degenerative processes and is replaced by fibrous connective tissue.

Another theory - the cellular survival theory - suggests that since mature adipocytes are very fragile cells, only the preadipocytes and the adipose-derived stem cells survive the transplant process. Since there is variability of these cells between patients, this could be why some patients' fat grafts last much longer than others. 2

So, the primary challenge for the physician is to find effective methods to >increase the survival of transplanted adipose cells and tissue.

Fortunately, platelet-rich plasma (PRP) can be used in fat grafting to overcome this problem and increase the survivability of transplanted fat cells .

How does PRP work?

PRP stimulates the body's innate healing cascade. When we experience a soft tissue injury, our body responds by delivering a rush of platelet cells. When these platelets are activated, they release several types of growth factors, proteins, and cytokines that play a fundamental role in cell regeneration and tissue healing.

But PRP takes the natural healing response one step further by separating platelets from other blood components and concentrating them. This specially prepared platelet-rich plasma contains 5 to 10 times the concentration of platelets found in whole blood. The concentrated PRP is then delivered into and around the site of injury via injection, stimulating and significantly strengthening the body's healing response. 3

Since PRP is an autologous therapy, using the patient's own blood product, there is no risk of cross reactivity, disease transmission, or immune reaction.

There have been several studies backing up the benefits of PRP with fat grafting. When PRP with fat grafting was used for breast enhancement, as well as forehead and cheek augmentation, researchers found that an increased percentage of PRP used in a fat graft directly increased the percentage of contour restoration that was maintained 4.

PRP also has been shown to enhance the survival and volume retention of autologous fat grafts, including youthful cheek definition and breast fullness that lasts for over a year after the graft. 5 Additionally, injecting fat mixed with platelet-rich fibrin (PRF) matrix can help increase fat survival. 6


To create a platelet-rich plasma preparation, the following steps are performed:

  1. A small sample of blood is drawn from the patient and injected into the Dr. PRP blood tube.
  2. The platelets are then separated from the other blood components and their concentration is increased using the Dr. PRP centrifuge.
  3. The resulting platelet-rich plasma is then injected into and around the targeted site of the patient.
  4. The concentrated growth factors contained in the plasma trigger a mild inflammatory response which effectively jump starts and strengthens the body's own natural healing response.

The entire process takes approximately one hour, including preparation and recovery time. For a complete demonstration of each step of the process, view our instructional video.


The Dr. PRP is an FDA-cleared medical device, holding the esteemed 510K clearance, meticulously designed to prepare patients' blood for PRP therapy quickly and efficiently.

Our patented design creates high-concentration and high-quality platelet-rich plasma that can be used to stimulate the healing process. This results in tissue regeneration at the targeted site, effectively accelerating normal healing processes.




  • Completely closed, sterile system.
  • Outside air is blocked with a double safety cap.
  • Since the processing is completed within the closed system, there is no risk of the PRP becoming contaminated.


  • Each kit comes pre-packaged.
  • The clear chambers ensure that you can see all the components of the blood sample.
  • The buffy coat layer is easily seen in the neck of the device, allowing you to precisely separate the components into the type of PRP you wish to produce.
  • You can even eliminate red blood cells from your final PRP product.


  • The closed system allows for more treatments in less time.
  • Customize your final PRP composition for use in different situations.
  • The PRP can and should be administered as soon as you prepare it with our kit - no advanced preparation is needed.


  • One kit holds 20 cc of fluid (3 cc of anti-coagulant + 17 cc of whole blood) and produces 4 cc of highly concentrated PRP.
  • The platelet recovery percentage of Dr. PRP is higher than the minimum recovery percentage of other similar products from our competitors.


  • Platelets require red and white blood cells to survive long-term. Unlike gel separators that capture the platelets within the gel, our kit allows you to accurately create consistently efficient PRP at the concentrations you want.


  • Our kit can recover 90% of platelets from a blood sample to produce the highest quality PRP.


  • The kit is now proudly holding the FDA 510K clearance.


  • According to the ISO 13485, our kit is made with a thorough gamma-ray sterilization system.
  • Made only with biocompatibility-certification completed raw materials.


  • One-on-one, in-service training is provided via GoToTraining, FaceTime, or Skype.
  • User Manual with photos and descriptions detail how to use your new product, as well as information on PRP and test results.
  • Enroll in our Platelet-Rich Plasma CME Certification course where you can learn cosmetic applications of PRP, including the PRP Facial and PRP Facelift.


  • Order marketing materials and educational brochures for your patients. These brochures explain various applications of PRP, such as sports medicine and hair regeneration.
  • Add your contact information and location to our Directory of PRP Providers .

To view and order Dr. PRP kits and centrifuges, visit our online store.

For questions and to discuss our products in more detail, contact us today at 844-377-7787 (DR- PRP-US).


  4. Valerio Cervelli, et. al., “P.R.L. Platelet Rich Lipotransfert: Our Experience and Current State of Art in the Combined Use of Fat and PRP,” BioMed Research International, (2013): 1-9, accessed January 21, 2020, doi: 10.1155/2013/434191
  5. Kevin S. Sadati, Robert W. Alexander, and Anthony C. Corrado, “Platelet-Rich Plasma (PRP) Utilized to Promote Greater Graft Volume Retention in Autologous Fat Grafting,” The American Journal of Cosmetic Surgery 23 , no. 4 (2006): 203–11, accessed January 21, 2020, doi:10.1177/074880680602300407.
  6. Richard M. Goldfarb and Aaron L. Shapiro, “Benefits of Autologous Fat Grafting Using Fat Mixed with Platelet-Rich Fibrin Matrix (PRFM) Selphyl,” The American Journal of Cosmetic Surgery 29, no. 1 (2012): 62–64, accessed January 21, 2020, doi:10.5992/AJCS-D-11-00037.1.