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PRP for Soft Tissue Regeneration

Musculoskeletal conditions and injuries are the most common cause of physical disability and severe chronic pain. Millions of people around the world suffer from these problems, which include osteoarthritis, tendonitis, bursitis, and problems with the ligaments, cartilage, and fascia. These conditions result in lost wages, decreased productivity, and diminished quality of life.1

Standard treatment options for musculoskeletal and soft tissue injury include:

  • Drug therapy like painkillers and cortisone injections
  • Rehabilitation therapy
  • Surgery

However, all these options have potential drawbacks. Some patients are unable to invest the time required for rehabilitation therapy. Surgery, the most invasive option, carries high costs and higher risks. Cortisone injections, while having a lower financial and time investment, can result in elevated blood sugar, tendon injury, cartilage loss, joint infection, osteoporosis, and death of nearby bone.2 Cortisone injections also do nothing to heal the tissue. Rather, they aim to temporarily reduce the pain and inflammation at the site of injury.

So, it doesn’t make sense to be injecting something into our patients that could result in more musculoskeletal injury.

Platelet-rich plasma, or PRP, is showing great promise as a regenerative therapy in musculoskeletal conditions. Rather than temporarily suppressing inflammation, PRP has been shown to regenerate damaged tissue in experimental studies.3

But how does it work? PRP stimulates the body’s innate healing cascade. When we experience a soft tissue injury, our body responds by delivering a rush of platelets. When these platelets are activated, they release several types of growth factors, proteins, and cytokines that play a fundamental role in cell regeneration and tissue healing.

But PRP takes the natural healing response one step further by separating the platelets from other blood components and concentrating them. This specially prepared platelet-rich plasma contains 5 to 10 times the concentration of platelets found in whole blood. The concentrated PRP is then delivered into and around the site of injury via injection, stimulating and significantly strengthening the body’s healing response.4

Since PRP is an autologous therapy, using the patient’s own blood product, there is no risk of cross reactivity, disease transmission, or immune reaction.

In musculoskeletal tissues in particular, the healing process takes a long time due to slow cell turnover and limited blood supply.5 Injecting platelet-rich plasma directly into the injured tissue speeds up the formation of new blood vessels – increasing the blood supply and delivery of nutrients needed for cell regeneration.6

Studies have shown that PRP injections resulted in improved function, less pain and swelling, and shorter rehabilitation time.7 The research suggests PRP is an effective treatment option for patellar and Achilles tendinopathies8 and osteochondral lesions of the talus – one of the most common ankle problems.9 PRP was also found to be effective in reducing functional limitations, pain, and stiffness in patients with knee osteoarthritis.10

PRP often results in long-lasting healing and pain relief from musculoskeletal conditions including:

  • Back and neck injuries
  • Pelvic pain and instability
  • Osteoarthritis of the knee, hip, shoulder, and spine
  • Tendonitis
  • Tennis elbow
  • Rotator cuff injuries
  • Chronic plantar fasciitis11

Platelet-rich plasma therapy can be used as the primary treatment or as an adjunct to surgical repair.


THE PRP PROCESS

To create a platelet-rich plasma preparation, the following steps are performed:

  1. A small sample of blood is drawn from the patient and injected into the Dr. PRP blood tube.
  2. The platelets are then separated from the other blood components and their concentration is increased using the Dr. PRP centrifuge and removal of some of the plasma.
  3. The resulting platelet-rich plasma is then injected into and around the injured site of the patient.
  4. The concentrated growth factors contained in the plasma trigger a mild inflammatory response which effectively jump starts the body’s own natural healing response.

The entire process takes approximately one hour, including preparation and recovery time. For a complete demonstration of each step of the process, view our instructional video.

How To Use DrPRP Kits

DR. PRP

The Dr. PRP is an FDA-cleared medical device, holding the esteemed 510K clearance, meticulously designed to prepare patients' blood for PRP therapy quickly and efficiently.

Our patented design creates high-concentration and high-quality platelet-rich plasma that can be used by your physician to stimulate the healing process. This may result in tissue regeneration at the injured site, effectively accelerating normal healing processes.

REACH OUT TO LEARN MORE

BENEFITS OF DR. PRP

SAFETY
  • Completely closed, sterile system.
  • Outside air is blocked with a double safety cap.
  • Since the processing is completed within the closed system, there is no risk of the PRP becoming contaminated.
EASY TO USE
  • Each kit comes pre-packaged.
  • The clear chambers ensure that you can see all the components of the blood sample.
  • The buffy coat layer is easily seen in the neck of the device, allowing you to precisely separate the components into the type of PRP you wish to produce.
  • You can even eliminate red blood cells from your final PRP product.
QUICK AND CONVENIENT
  • The closed system allows for more treatments in less time.
  • Customize your final PRP composition for use in different situations.
  • The PRP can and should be administered as soon as you prepare it with our kit – no advanced preparation is needed.
HIGH CONCENTRATION
  • One kit holds 20 cc of fluid (3 cc of anticoagulant + 17 cc of whole blood) and produces 4 cc of highly concentrated PRP or 10 cc of a lower concentration.
  • The platelet recovery percentage of Dr. PRP is higher than the minimal recovery percentage of other similar products from our competitors.
CONSISTENT RESULTS
  • Platelets require red and white blood cells to survive long-term. Unlike gel separators that capture the platelets within the gel, our kit allows you to accurately create consistently efficient PRP at the concentrations you desire.
QUALITY
  • Our kit can recover over 90% of platelets from a blood sample to produce the highest quality PRP.
FDA 510K CLEARED
  • The kit is now proudly holding the FDA 510K clearance.
PATENTED DESIGN
  • According to the ISO 13485, our kit is made with a thorough gamma-ray sterilization system.
  • Made only with biocompatibility-certification completed raw materials.
TRAINING & SUPPORT
  • One-on-one, in-service training is provided via GoToTraining, FaceTime, or Zoom.
  • User Manual with photos and descriptions detail how to use your new product, as well as information on PRP and test results.
  • Enroll in our Platelet-Rich Plasma CME Certification course where you can learn cosmetic applications of PRP, including the PRP Facial and PRP Facelift.
MARKETING SYSTEM
  • Order marketing materials and educational brochures for your patients. These brochures explain various applications of PRP, such as sports medicine and hair regeneration.
  • Add your contact information and location to our Directory of PRP Providers.

To view and order Dr. PRP kits and centrifuges, visit our online store. For questions and to discuss our products in more detail, contact us today at 844-377-7787 (DR- PRP-US).

References

  1. Ivan Dimauro, Loredana Grasso, Simona Fittipaldi, Cristina Fantini, Neri Mercatelli, Silvia Racca, Stefano Geuna, Alessia Di Gianfrancesco, Daniela Caporossi, Fabio Pigozzi, and Paolo Borrione. "Platelet-Rich Plasma and Skeletal Muscle Healing: A Molecular Analysis of the Early Phases of the Regeneration Process in an Experimental Animal Model" PLoS ONE 2014; 9(7): e102993, accessed June 18, 2021, 10.1371/journal.pone.0102993.
  2. "Cortisone shots" Mayo Clinic Accessed 18 June 2021. https://www.mayoclinic.org/tests-procedures/cortisone-shots/about/pac-20384794
  3. Kaux JF, Crielaard JM. "Platelet-rich plasma application in the management of chronic tendinopathies." Acta Orthopaedica Belgica 2013 Feb;79(1):10-5. PMID: 23547508.
  4. "PRP Injections for Pain" American Academy / Association of Orthopedic Medicine Accessed 18 June 2021. https://www.aaomed.org/Platelet-Rich-Plasma-Injections-for-Pain
  5. Boswell SG, Cole BJ, Sundman EA, Karas V, Fortier LA. "Platelet-rich plasma: a milieu of bioactive factors." Arthroscopy. 2012 Mar;28(3):429-39. doi: 10.1016/j.arthro.2011.10.018. Epub 2012 Jan 28. PMID: 22284405.
  6. Voja Pavlovic, Milan Ciric, Vladimir Jovanovic, and Predrag Stojanovic. "Platelet Rich Plasma: a short overview of certain bioactive components." Open Medicine. 2016; 11(1): 242–247. doi: 10.1515/med-2016-0048
  7. Ivan Dimauro, Loredana Grasso, Simona Fittipaldi, Cristina Fantini, Neri Mercatelli, Silvia Racca, Stefano Geuna, Alessia Di Gianfrancesco, Daniela Caporossi, Fabio Pigozzi, and Paolo Borrione. "Platelet-Rich Plasma and Skeletal Muscle Healing: A Molecular Analysis of the Early Phases of the Regeneration Process in an Experimental Animal Model" PLoS ONE 2014; 9(7): e102993, accessed June 18, 2021, 10.1371/journal.pone.0102993.
  8. Di Matteo B, Filardo G, Kon E, Marcacci M. "Platelet-rich plasma: evidence for the treatment of patellar and Achilles tendinopathy--a systematic review." Musculoskelet Surgery. 2015 Apr;99(1):1-9. doi: 10.1007/s12306-014-0340-1. Epub 2014 Oct 17. PMID: 25323041.
  9. Akpancar S, Gül D. "Comparison of Platelet Rich Plasma and Prolotherapy in the Management of Osteochondral Lesions of the Talus: A Retrospective Cohort Study." Medica Science Monitor. 2019 Jul 30;25:5640-5647. doi: 10.12659/MSM.914111. PMID: 31358724; PMCID: PMC6685325.
  10. Poupak Rahimzadeh, Farnad Imani, Seyed Hamid Reza Faiz, Saeed Reza Entezary, Mahnaz Narimani Zamanabadi, and Mahmoud Reza Alebouyeh. "The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis." Clinical Interventions in Aging. 2018; 13: 73–79. Published online 2018 Jan 4. doi: 10.2147/CIA.S147757
  11. "PRP Injections for Pain" American Academy / Association of Orthopedic Medicine Accessed 18 June 2021. https://www.aaomed.org/Platelet-Rich-Plasma-Injections-for-Pain
References