Prolotherapy is a treatment used to repair joints and ligaments, and PRP can help heal injuries to soft tissues like meniscus, Achilles tendon, rotator cuff, muscle, and bone damage. Both PRP and prolotherapy were found to be successful at treating osteochondral lesions of the talus.1 PRP was also found to be more effective at reducing functional limitations, pain, and stiffness in patients with knee osteoarthritis.2
Serkan Akpancar and Deniz Gül, “Comparison of Platelet Rich Plasma and Prolotherapy in the Management of Osteochondral Lesions of the Talus: A Retrospective Cohort Study,” Medical Science Monitor: International Medical Journal of Experimental and Clinical Research 25, (2019): 5640-47, accessed December 9, 2019, doi: 10.12659/MSM.914111.
Poupak Rahimzadeh, et. al., “The effects of injecting intra-articular platelet-rich plasma or prolotherapy on pain score and function in knee osteoarthritis,” Clinical Interventions in Aging 13, (2018): 73-79, accessed December 12, 2019, doi: 10.2147/CIA.S147757.