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PRP for Wound Healing

When we burn our skin, get a laceration, or have another type of skin injury, our body’s healing process gets to work immediately to heal the wound. But sometimes wounds don’t heal like they should.

Millions of people around the world suffer from skin wounds caused by burns, surgeries, infections, and pressure ulcers.1 As the population gets older, degenerative diseases continue to rise – leading to chronic wounds associated with vascular issues and diabetes.

Chronic wounds are any wounds that don’t progress through the normal phases of healing in a timely manner. They typically include diabetic foot ulcers, venous leg ulcers, and pressure ulcers. These ulcers can last 12 to 13 months and recur in 60% to 70% of patients. They often lead to loss of function, decreased quality of life, and can even become a significant cause of morbidity.2

Chronic wounds are becoming more prevalent and more difficult to treat and are associated with high treatment costs. Because of this, there’s an urgent need to explore novel approaches to improve wound healing.

Platelet-rich plasma, or PRP, is gaining attention as an effective treatment for wound healing. To learn why, let’s take a deeper look into the healing process of cutaneous wounds.


Wound Healing Process

The wound healing process is typically divided into four overlapping phases:

  1. Hemostasis
  2. Inflammation
  3. Cell proliferation
  4. Remodeling

Any injury to the skin is immediately dealt with by the body’s natural healing cascade. But chronic wounds often stall in the inflammation phase. They continue to attract more inflammatory cells without ever progressing to the proliferative phase. There are many problems presented by chronic wounds, including:

  • Prolonged inflammation
  • Persistent infections
  • Formation of drug-resistant microbial biofilms
  • Inability of dermal and/or epidermal cells to respond to reparative stimuli3

All of these factors lead to failure in achieving complete wound healing.

Platelet-rich plasma (PRP) has demonstrated effectiveness in wound care. Regenerative therapies like PRP are considered the gold-standard for accelerating wound healing as they’re minimally invasive, safe, and cost-effective. They’ve also been shown to result in a shortened recovery period and, therefore, an improved quality of life for patients.4

Recent research has shown PRP to be more effective than conventional means – like staples, sutures, or glue – in acting as an adhesive for skin grafts. PRP has adhesive, hemostatic, and healing properties that make it an ideal choice for adhering skin grafts to wounds.5 PRP was also shown to result in better wound healing, decreased scar development, and reduced pain after split-thickness skin grafting (STSG).6

The high concentration of platelets in PRP also plays an important role in infection control at the wound site. Studies of PRP have demonstrated antimicrobial activity against:

  • Escherichia coli
  • Staphylococcus aureus, including methicillin-resistant Staphylococcus aureus7
  • Candida albicans
  • Cryptococcus neoformans8

This property makes PRP an invaluable addition to wound care protocols since infection control is always a primary concern in treating open wounds.

PRP is used as an adjunctive treatment in wound care, along with standard protocols which may include debridement, compression, and frequent dressing changes.


THE PRP PROCESS

To create a platelet-rich plasma preparation, the following steps are performed:

  1. A small sample of blood is drawn from the patient and injected into the Dr. PRP blood tube.
  2. The platelets are then separated from the other blood components and their concentration is increased using the Dr. PRP centrifuge and by removing some of the plasma.
  3. The resulting platelet-rich plasma is then applied onto and around the injured site of the patient.
  4. The concentrated growth factors contained in the plasma trigger a mild inflammatory response which effectively jump starts the body’s own natural healing response.

The entire process takes approximately one hour, including preparation and recovery time. For a complete demonstration of each step of the process, view our instructional video.


DR. PRP

The Dr. PRP is an FDA-registered medical device designed to quickly and efficiently prepare patients’ blood for PRP therapy.

Our patented design creates high-concentration and high-quality platelet-rich plasma that can be used by your physician to stimulate the healing process. This may result in tissue regeneration at the injured site, effectively accelerating normal healing processes.

REACH OUT TO LEARN MORE

BENEFITS OF DR. PRP

SAFETY
  • Completely closed, sterile system.
  • Outside air is blocked with a double safety cap.
  • Since the processing is completed within the closed system, there is no risk of the PRP becoming contaminated.
EASY TO USE
  • Each kit comes pre-packaged.
  • The clear chambers ensure that you can see all the components of the blood sample.
  • The buffy coat layer is easily seen in the neck of the device, allowing you to precisely separate the components into the type of PRP you wish to produce.
  • You can even eliminate red blood cells from your final PRP product.
QUICK AND CONVENIENT
  • The closed system allows for more treatments in less time.
  • Customize your final PRP composition for use in different situations.
  • The PRP can and should be administered as soon as you prepare it with our kit – no advanced preparation is needed.
HIGH CONCENTRATION
  • One kit holds 20 cc of fluid (3 cc of anticoagulant + 17 cc of whole blood) and produces 4 cc of highly concentrated PRP or 10 cc of a lower concentration.
  • The platelet recovery percentage of Dr. PRP is higher than the minimal recovery percentage of other similar products from our competitors.
CONSISTENT RESULTS
  • Platelets require red and white blood cells to survive long-term. Unlike gel separators that capture the platelets within the gel, our kit allows you to accurately create consistently efficient PRP at the concentrations you desire.
QUALITY
  • Our kit can recover over 90% of platelets from a blood sample to produce the highest quality PRP.
FDA REGISTERED
  • The kit is registered by the US-FDA for regenerative use by healthcare providers.
  • The FDA 510K is pending approval.
PATENTED DESIGN
  • According to the ISO 13485, our kit is made with a thorough gamma-ray sterilization system.
  • Made only with biocompatibility-certification completed raw materials.
TRAINING & SUPPORT
  • One-on-one, in-service training is provided via GoToTraining, FaceTime, or Zoom.
  • User Manual with photos and descriptions detail how to use your new product, as well as information on PRP and test results.
  • Enroll in our Platelet-Rich Plasma CME Certification course where you can learn cosmetic applications of PRP, including the PRP Facial and PRP Facelift.
MARKETING SYSTEM
  • Order marketing materials and educational brochures for your patients. These brochures explain various applications of PRP, such as sports medicine and hair regeneration.
  • Add your contact information and location to our Directory of PRP Providers.

To view and order Dr. PRP kits and centrifuges, visit our online store. For questions and to discuss our products in more detail, contact us today at 844-377-7787 (DR- PRP-US).

References

  1. Deborah Chicharro-Alcántara, Mónica Rubio-Zaragoza, Elena Damiá-Giménez, José M. Carrillo-Poveda, Belén Cuervo-Serrato, Pau Peláez-Gorrea, and Joaquín J. Sopena-Juncosa. "Platelet Rich Plasma: New Insights for Cutaneous Wound Healing Management" Journal of Functional Biomaterials (March 2018), accessed June 18, 2021, doi: 10.3390/jfb9010010.
  2. Robert G. Frykberg and Jaminelli Banks. "Challenges in the Treatment of Chronic Wounds" Advances in Wound Care (September 2015): 560-582, accessed June 18, 2021, doi: 10.1089/wound.2015.0635.
  3. Robert G. Frykberg and Jaminelli Banks. "Challenges in the Treatment of Chronic Wounds" Advances in Wound Care (September 2015): 560-582, accessed June 18, 2021, doi: 10.1089/wound.2015.0635.
  4. Deborah Chicharro-Alcántara, Mónica Rubio-Zaragoza, Elena Damiá-Giménez, José M. Carrillo-Poveda, Belén Cuervo-Serrato, Pau Peláez-Gorrea, and Joaquín J. Sopena-Juncosa. "Platelet Rich Plasma: New Insights for Cutaneous Wound Healing Management" Journal of Functional Biomaterials (March 2018), accessed June 18, 2021, doi: 10.3390/jfb9010010.
  5. Veena P Waiker, Shanthakumar Shivalingappa. "Comparison between Conventional Mechanical Fixation and Use of Autologous Platelet Rich Plasma (PRP) in Wound Beds Prior to Resurfacing with Split Thickness Skin Graft" World Journal of Plastic Surgery (January 2015): 50-9, accessed June 18, 2021, PMID: 25606477; PMCID: PMC4298865.
  6. Fang Z, Yang X, Wu G, Liu M, Han J, Tao K, Hu D. "The use of autologous platelet-rich plasma gel increases wound healing and reduces scar development in split-thickness skin graft donor sites." Journal of Plastic Surgery and Hand Surgery." 2019 Dec;53(6):356-360. doi: 10.1080/2000656X.2019.1635489. Epub 2019 Jul 3. PMID: 31268389.
  7. Bielecki TM, Gazdzik TS, Arendt J, Szczepanski T, Król W, Wielkoszynski T. "Antibacterial effect of autologous platelet gel enriched with growth factors and other active substances: an in vitro study." The Journal of Bone and Joint Surgery British volume. 2007 Mar;89(3):417-20. doi: 10.1302/0301-620X.89B3.18491. PMID: 17356164.
  8. Tang YQ, Yeaman MR, Selsted ME. "Antimicrobial peptides from human platelets." Infection and Immunity Journal 2002 Dec;70(12):6524-33. doi: 10.1128/IAI.70.12.6524-6533.2002. PMID: 12438321; PMCID: PMC132966.