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Use of Platelet-Rich Plasma (PRP) in Patients with Cerebral Palsy

Published: 09/28/2020
PRP Use in Patients with Cerebral Palsy

PRP (Platelet Rich Plasma) therapy is a form of regenerative medicine prepared from a sample of a patient's own blood. The concentration of platelets is used to treat many diseases, including (as research suggests) cerebral palsy.

A study on PRP treatment in the American Journal of Case Reports suggests that even a single treatment may be able to help with symptoms of cerebral palsy, the effects being seen even half a year later.

If you’re interested in treating cerebral palsy patients with PRP, read on to see what PRP for cerebral palsy seemed to do for one young patient.

Can PRP Treat Cerebral Palsy?

One study analyzed the effects of a PRP injection on a six-year-old boy with cerebral palsy. Both three and six months after the injection, cognitive symptoms seemed to improve, such as his ability to eat solid food, his coordinated movements, and speaking ability. Changes in the patient’s cerebral cortex were also seen via a positron emission tomography scan six months post treatment.

Compared to their levels of the day of the injection, the boy’s plasma levels of the following growth factors were also higher than average three and six months afterward1:

  • platelet-derived growth factor (PDGF)
  • transforming growth factor B (TGF-B)
  • vasculo-endothelial growth factor (VEGF)
  • insulin-1 (IGF-1)

The platelets in PRP release growth factors, and the growth factors may have positive effects on neural tissue. TGF-beta may be able to help neural stem cells differentiate, VEGF may be able to help with blood vessel air permeability via neural cell differentiation and chemotaxis, and IGF-1 may be able to help neural progenitor stem cells undergo mitosis.2

  1. Jesús Alcaraz, Antonio Oliver, and Juana María Sánchez, “Platelet-Rich Plasma in a Patient with Cerebral Palsy,” The American Journal of Case Reports 16, (2015): 469-72, accessed August 20, 2020, doi: 10.12659/AJCR.893805.
  2. Jesús Alcaraz Rubio and Juana María Sánchez López, “Plasma Growth Factors in Cerebral Palsy,” in Cerebral Palsy - Clinical and Therapeutic Aspects, IntechOpen, December 19, 2018, doi: 10.5772/intechopen.80369.